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Nanotechnology in Tissue Engineering: Nanotechnology is at present being used for engineered tissue and regenerative medicine . Nanostructures can imitate tissue-particular bio conditions by outlining builds with specific biochemical, mechanical and electrical properties. Along this, tissue can be designed by utilizing these nanostructures for upgraded cell grip, development and separation.  Carbon nanotubes for bone tissue engineering: Bone tissue building requires the development of cell composes, for example, osteoblasts, osteoclasts and osteocytes inside a non-cell mineral part. Beforehand, nanomaterials chosen for bone tissue designing were constrained because of their low mechanical quality. Multi-walled carbon nanotubes have additionally been demonstrated to deliver bone repair that can be completely incorporated into new bone. Later on, bone tissue engineering could be applied during hard tissue surgery, particularly for reinforcing artificial bone im
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Natural ways to heal wounds Using chemicals often have a hostile effect on our skin. So, we can use these natural ingredients to treat cuts without worrying about any side effects. So instead of applying chemicals in the wounded area, we can use natural ingredients to heal wounds . Honey: Honeys wound care capacities, an attribute that can help a contaminated injury appropriately. From consume wounds, bacterial contaminations to ulcers; honey is a regular hose hold item that can give various healing benefits. One of the greatest clean highlights of honey is its capacity to discharge hydrogen peroxide that is fundamental for wiping out bacterial action. The pollen collected and transformed into honey has been known to adequately treat genuine diseases, extending from skin rashes, bubbles to singed skin. Honeys’ properties are in the religious books like Bible, Torah, and Quran. Since 2000 BC, individuals have been utilizing Honey to heal cuts. Honey contains vitamins,
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SOFT TISSUE HEALING Soft tissues are those tissues that connect and support the body, these include muscles, tendons, ligaments, fascia, nerves, fibrous tissues, fat, blood vessels.This classification is based on a treatment protocol. But some time phases overlap and dependable on the individual response to healing and the type of injury. Inflammatory phase: The acute inflammatory response is of relatively quite long   duration and involves activities that generate exudates- plasma like fluid that exudes out of tissue or its capillaries and is composed of protein and granular leukocytes (white blood cells).In the Chronic inflammatory response is of prolonged duration and involves the presence of nongranular leukocytes and the production of scar tissue. Proliferative phase: Formation of granulation tissue is a central event during the proliferative phase. Its formation occurs 3-5 days following injury and overlaps with the preceding inflammatory
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Scaffolds for Cartilage Tissue Engineering: Tissue engineered additive manufactured scaffolds for cartilage repair , shows high prospective for growing adult cartilage tissue. Articular cartilage is the connective tissue that allows for the frictionless movement of bone within the synovial joints of the body. Its extracellular matrix consists of a combination of different types of collagen and proteoglycans that together are responsible for the viscoelastic and swelling properties of the tissue. Both natural and synthetic polymers have considered as substrate materials for the fabrication of 3D support structures. While natural source compounds, such as gelatin and alginates, are more bioactive and truly biodegradable, synthetic polymers are more predictable, reproducible, and scalable in terms of chemical and physical properties and offer a stronger structural support. Depending on the chosen scaffold fabrication technique and the end-application, both types of resour
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Strategies for Human Adipose Tissue Repair and Regeneration: Adipose tissue is an extremely vascularized connective tissue in the human body. It is responsible for energy storage and release of a number of adipokines that may act in an endocrine or paracrine manner. It is also a highly plastic tissue than can increase energy depots by hypertrophic growth and hyperplasic expansion of adipose stromal cells (ASCs). It contains many cell types including adipocytes, endothelial cells (ECs), fibroblasts, macrophages and leukocytes. The human adipose tissue can be found either in the white adipose tissue (WAT) or the brown adipose tissue (BAT) form. Tissue engineering is the interdisciplinary field where materials, cells, growth factors and other bioactive molecules are combined together to make transplantable constructs, the final goal being to promote repair and regeneration of damaged tissue . Loss or damage of adipose tissue needs repair and regenerative approaches not only for
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Role of Myofibroblast in normal and pathological tissue repair Tissue repair is an essential phenomenon allowing tissues and organs to recover functional properties that have been lost after an injury, either linked to a wound or to a disease. In fetal or embryonic wounds that repair without a scar or fibrosis, normal repair in the adult always leads to scar formation. In these processes of   myofibroblat   play a crucial role. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical tissue organization, a process essentially supported by myofibroblasts. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete. Normal wound healing After injury the healing process allow immediately restoration of injured tissue. Wound healing proceeds in three interrelated stages with overlapping time Period. According to morphologica
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Stem Cell-Based Therapy for Wounds Stem cells offer noteworthy prospects giving both undifferentiated and separated cells for gene therapy, drug discovery, and regenerative medicine. Wound repair is a composite process and is impacted by various factors, including cytokines, chemokines, and development factors. Hypothetically, utilization of stem cells to wounds is valuable, because it has a remarkable component of interfacing with wound condition and adjusts their movement to discharge different variables, which encourage wound recovering process. 1. Embryonic Stem Cells (ESCs) Embryonic stem cells (ESCs) are pluripotent in nature which reside within the blastocyst. These cells have a potential to differentiate into any of the three primary germ layers namely endoderm, mesoderm, or ectoderm. These cells can be differentiated into keratinocytes in presence of selected medium containing specific growth factors. These keratinocytes are capable of forming multilayered epider
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