Implication in Bone Regeneration Therapy:
Nanocomposite hydrogels have recently grow to be an exciting challenge of examine for tissue engineering. These scaffolds represent a combination of polymers and other nanomaterials that display unique capabilities in comparison to traditional hydrogels. Mainly, the presences of nanomaterials can build mechanical homes of scaffolds and the manual tactics of cellular adhesion and proliferation.
Nano diamonds have considered as drug delivery nano carriers due to their low cytotoxicity and superficial surface function. So these Nano diamonds have been recently considered for the fabrication of nanocomposite hydrogels for tissue engineering. The production of a hydrogel using photo cross linkable gelatin meth acrylamide and Nano diamonds as a three dimensional scaffold for drug delivery and stem cell conducted bone regeneration. The presence of Nano diamonds improved stiffness, which in order augmented the adhesion forces generated by human adipose stem cells. The capability of Nano diamonds to adsorb and modulate the release of a model drug dexamethasone to promote the osteogenic differentiation of human adipose stem cells.
 The Nano diamonds-dexamethasone complexes modified gene expression, cell area, and focal adhesion number in human adipose stem cells. Moreover, the combination of the Nano diamonds-dexamethasone complex within gelatin meth acrylamide hydrogels permitted a higher retention of dexamethasone, resulting in expressively improved alkaline phosphatase activity and calcium deposition of encapsulated human adipose stem cells. These consequences that conventional gelatin meth acrylamide hydrogels can be coupled with conjugated Nano diamonds to develop a different platform for bone tissue engineering.

To know more about Bone Regeneration Therapies and its applications, visit our upcoming 10th Tissue Repair and Regeneration Congress at Dubai.

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