tissuerepair2018

Strategies for Human Adipose Tissue Repair and Regeneration: Adipose tissue is an extremely vascularized connective tissue in the human body. It is responsible for energy storage and release of a number of adipokines that may act in an endocrine or paracrine manner. It is also a highly plastic tissue than can increase energy depots by hypertrophic growth and hyperplasic expansion of adipose stromal cells (ASCs). It contains many cell types including adipocytes, endothelial cells (ECs), fibroblasts, macrophages and leukocytes. The human adipose tissue can be found either in the white adipose tissue (WAT) or the brown adipose tissue (BAT) form. Tissue engineering is the interdisciplinary field where materials, cells, growth factors and other bioactive molecules are combined together to make transplantable constructs, the final goal being to promote repair and regeneration of damaged tissue . Loss or damage of adipose tissue needs repair and regenerative approaches not only for

Role of Myofibroblast in normal and pathological tissue repair Tissue repair is an essential phenomenon allowing tissues and organs to recover functional properties that have been lost after an injury, either linked to a wound or to a disease. In fetal or embryonic wounds that repair without a scar or fibrosis, normal repair in the adult always leads to scar formation. In these processes of   myofibroblat   play a crucial role. When tissues are damaged, tissue homeostasis must be re-established, and repair mechanisms have to rapidly provide harmonious mechanical tissue organization, a process essentially supported by myofibroblasts. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete. Normal wound healing After injury the healing process allow immediately restoration of injured tissue. Wound healing proceeds in three interrelated stages with overlapping time Period. According to morphologica

Stem Cell-Based Therapy for Wounds Stem cells offer noteworthy prospects giving both undifferentiated and separated cells for gene therapy, drug discovery, and regenerative medicine. Wound repair is a composite process and is impacted by various factors, including cytokines, chemokines, and development factors. Hypothetically, utilization of stem cells to wounds is valuable, because it has a remarkable component of interfacing with wound condition and adjusts their movement to discharge different variables, which encourage wound recovering process. 1. Embryonic Stem Cells (ESCs) Embryonic stem cells (ESCs) are pluripotent in nature which reside within the blastocyst. These cells have a potential to differentiate into any of the three primary germ layers namely endoderm, mesoderm, or ectoderm. These cells can be differentiated into keratinocytes in presence of selected medium containing specific growth factors. These keratinocytes are capable of forming multilayered epider