Implication in Bone Regeneration Therapy:
Nanocomposite
hydrogels have recently grow to be an exciting challenge of examine for tissue engineering. These scaffolds represent a combination of
polymers and other nanomaterials
that display unique capabilities in
comparison to traditional hydrogels. Mainly, the presences of
nanomaterials can build mechanical homes of scaffolds and the manual tactics of
cellular adhesion and proliferation.
Nano diamonds have considered as drug
delivery nano carriers due to their low cytotoxicity and superficial surface
function. So these Nano diamonds have been recently considered for the
fabrication of nanocomposite hydrogels for tissue engineering. The production
of a hydrogel using photo cross linkable gelatin meth acrylamide and Nano
diamonds as a three dimensional scaffold for drug delivery and stem cell
conducted bone regeneration. The presence of Nano diamonds improved stiffness,
which in order augmented the adhesion forces generated by human adipose stem cells.
The capability of Nano diamonds to adsorb and modulate the release of a model
drug dexamethasone to promote the osteogenic differentiation of human adipose
stem cells.
The Nano diamonds-dexamethasone complexes modified
gene expression, cell area, and focal adhesion number in human adipose stem
cells. Moreover, the combination of the Nano diamonds-dexamethasone complex
within gelatin meth acrylamide hydrogels permitted a higher retention of dexamethasone,
resulting in expressively improved alkaline phosphatase activity and calcium
deposition of encapsulated human adipose stem cells. These consequences that
conventional gelatin meth acrylamide hydrogels can be coupled with conjugated
Nano diamonds to develop a different platform for bone tissue engineering.
To know more about Bone Regeneration
Therapies and its applications, visit our upcoming 10th Tissue
Repair and Regeneration Congress at Dubai.
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